CLDN18.2 (AA 28-76) protein (His tag)
This Recombinant CLDN18.2 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN8056939
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
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Quick Overview for CLDN18.2 (AA 28-76) protein (His tag) (ABIN8056939)
抗原
CLDN18.2
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % as determined by reducing SDS-PAGE.
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产品特性
- AA 28-76
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标记
- His tag
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原理
- Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag)
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序列
- Asp28-Leu76
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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CLDN18.2 protein (DYKDDDDK Tag)
宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc cryo-EM, ELISA, Imm, PhD, SPR
CLDN18.2 protein-VLP (DYKDDDDK Tag)宿主: 人 宿主: HEK-293 Cells VLP
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 25 mM NaCl, 0.1 % Triton X-100, 10 % glycerol, 0.1 mM GSH, 0.01 mM GSSG, pH 8.0.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- CLDN18.2
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背景
- CLDN18,Claudin-18,Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
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分子量
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Calculated MW: 19.7 kDa
Observed MW: 18 kDa
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基因ID
- 51208
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UniProt
- P56856
抗原
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