ADPRHL2 蛋白
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北京 101111
Quick Overview for ADPRHL2 蛋白 (ABIN7939788)
抗原
See all ADPRHL2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant ADPRS / ARH3 protein
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ADP-Ribosylhydrolase Like 2 (ADPRHL2) (AA 1-363) protein (His tag)
ADPRHL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
ADP-Ribosylhydrolase Like 2 (ADPRHL2) (AA 1-363) protein (GST tag)ADPRHL2 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
ADP-Ribosylhydrolase Like 2 (ADPRHL2) protein (Myc-DYKDDDDK Tag)ADPRHL2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant ADPRS / ARH3 protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- ADPRHL2 (ADP-Ribosylhydrolase Like 2 (ADPRHL2))
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别名
- ADPRS & ARH3
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背景
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Protein Background: Protein ADP-ribosylation is a highly dynamic post-translational modification. The rapid turnover is achieved, among others, by ADP (ribosyl)hydrolases (ARHs), an ancient family of enzymes that reverses this modification. Recently ARHs came into focus due to their role as regulators of cellular stresses and tumor suppressors. ADPRS / ARH3 (ADPribosylhydrolase ARH3) as one of ARHs, it plays a variety of functions in organisms.It preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos.
Short Description: Recombinant ADPRS / ARH3 protein that includes full length of the human ADPRS / ARH3 protein (accession number NP_060295.1) was expressed in E.coli cells with an N-terminal His tag, The molecular weight of the protein is 41.11 kDa.
Aliases: ADP-Ribosylserine Hydrolase, ARH3, ADPRHL2, ADPRS, ADPRHL2, FLJ20446
抗原
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