UBA1 蛋白
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北京 101111
Quick Overview for UBA1 蛋白 (ABIN7939723)
抗原
See all UBA1 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant UBA1 protein
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Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (AA 1-1058) protein (GST tag)
UBA1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)UBA1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant UBA1 protein is supplied in 25 mM HEPES pH 7.5, 500 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))
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别名
- UBA1
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背景
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Protein Background: UBA1 (Ubiquitin-like modifier-activating) also known as A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X and VEXAS. UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
Short Description: Recombinant UBA1 protein that includes full length of human UBA1 protein (accession number NP_003325.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with a molecular weight of 119.12 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: Ubiquitin-like modifier-activating, A1S9, A1S9T, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124
抗原
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