UBE2V1 蛋白
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北京 101111
Quick Overview for UBE2V1 蛋白 (ABIN7939671)
抗原
See all UBE2V1 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant UBE2V1 protein
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Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 1-147) protein (GST tag)
UBE2V1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)UBE2V1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag)UBE2V1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant UBE2V1 protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
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别名
- UBE2V1
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背景
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Protein Background: UBE2V1 (Ubiquitin-conjugating enzyme E2 variant 1) also known as CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1 and UEV1A. UBE2V1 has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of polyubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production.
Short Description: Recombinant UBE2V1 protein that includes full length of human UBE2V1 protein (accession number NP_001027459.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 18.66 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: Ubiquitin conjugating enzyme E2 variant 1, CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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