Tiparp 蛋白
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北京 101111
Quick Overview for Tiparp 蛋白 (ABIN7939640)
抗原
See all Tiparp 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant PARP7 protein
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 152,621.24 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PARP7 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- Tiparp (TCDD-Inducible Poly(ADP-Ribose) Polymerase (Tiparp))
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别名
- PARP7
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背景
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Protein Background: PARP7(Protein mono-ADP-ribosyltransferase TIPARP), also known as TiPARP, is a mono ADPribosyltransferase belonging to the Poly-ADP-ribose polymerase (PARP) family. Unlike some PARPs involved in DNA repair, PARP7's primary functions are linked to regulating gene expression and the immune response, particularly the type I interferon signaling pathway. It is induced by the transcription factor AHR (aryl hydrocarbon receptor) and acts as a negative feedback regulator. PARP7 modifies itself and other target proteins with a single ADP-ribose unit (MARylation), which influences their activity and stability. By MARylating key transcription factors like AHR and IRF3/7, it dampens inflammatory and interferon responses, thereby maintaining immune homeostasis. Its role as a checkpoint in anti-tumor immunity has made it a emerging target for cancer immunotherapy, where its inhibition is sought to enhance the body's innate immune attack against cancer cells.
Short Description: Recombinant PARP7 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_056323.2) with an N-terminal FLAG tag. The molecular weight of PARP7 is 77.5 kDa.
Aliases: Protein mono-ADP-ribosyltransferase TIPARP, TiPARP, ARTD14, DDF1, RM1, PART14
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途径
- Platelet-derived growth Factor Receptor Signaling
抗原
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