TARDBP Protein (AA 2-414)
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Quick Overview for TARDBP Protein (AA 2-414) (ABIN7939637)
抗原
See all TARDBP 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 2-414
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原理
- Recombinant TARDBP (2-414) protein
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TAR DNA Binding Protein (TARDBP) protein (Myc-DYKDDDDK Tag)
TARDBP 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
TAR DNA Binding Protein (TARDBP) (AA 1-414) protein (GST tag)TARDBP 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
TAR DNA Binding Protein (TARDBP) (AA 1-260) protein (GST tag)TARDBP 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
TAR DNA Binding Protein (TARDBP) (AA 1-414) protein (His tag)TARDBP 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
TAR DNA Binding Protein (TARDBP) (AA 8-192) protein (His-IF2DI Tag)TARDBP 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
TAR DNA Binding Protein (TARDBP) (AA 1-260) protein (His tag)TARDBP 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
TAR DNA Binding Protein (TARDBP) (AA 1-414) proteinTARDBP 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant TARDBP (2-414) protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- TARDBP (TAR DNA Binding Protein (TARDBP))
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别名
- TARDBP
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背景
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Protein Background: TARDBP (TAR DNA-binding protein 43) also known as ALS10 and TDP-43. TARDBP is a RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. In addition, TARDBP also has a variety of biological functions, such as plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts, regulates also mRNA stability, participates also in the normal skeletal muscle formation and regeneration, negatively regulates the expression of CDK6 and regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.
Short Description: Recombinant TARDBP (2-414) protein that includes amino acids 2-414 of human TARDBP protein (accession number NP_031401.1) was expressed in E. coli and contains an N-terminal His and FLAG tag with a molecular weight of 47.9 kDa. The purity of the protein is ≥ 60 % by SDS-PAGE.
Aliases: TAR DNA-binding protein 43, ALS10, TDP-43, TDP43
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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