STUB1 蛋白
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北京 101111
Quick Overview for STUB1 蛋白 (ABIN7939612)
抗原
See all STUB1 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant STUB1 / CHIP protein
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)
STUB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His-IF2DI Tag)STUB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant STUB1 / CHIP protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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别名
- STUB1 & CHIP
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背景
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Protein Background: STUB1 (E3 ubiquitin-protein ligase CHIP) also known as CHIP, HSPABP2, NY-CO-7, SCA48, SCAR16, SDCCAG7 and UBOX1. STUB1 is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes. Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90.
Short Description: Recombinant STUB1 / CHIP protein that includes full length of human STUB1 protein (accession number NP_005852.2) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 37.02 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: CHIP, SDCCAG7, UBOX1, E3 Ubiquitin Protein Ligase CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7
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途径
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
抗原
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