SUMO2 蛋白
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北京 101111
Quick Overview for SUMO2 蛋白 (ABIN7939590)
抗原
See all SUMO2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant SUMO2 protein - biotinylated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant SUMO2 protein - biotinylated is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))
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别名
- SUMO2
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背景
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Protein Background: SUMO2 (Small ubiquitin-related modifier 2) is a ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post translational modification on lysine residues of proteins plays a crucial role in several cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX.
Short Description: Recombinant SUMO2 protein - biotinylated that includes full length of human SUMO2 protein (accession number NP_008868.3) was expressed in E. coli and contains an N-terminal His & Avi tag with a molecular weight of 15.12 kDa. This protein has been modified by biotin in vivo. The purity of the protein is ≥ 70 % by SDS-PAGE.
Aliases: Small ubiquitin-related modifier 2, SMT3B, SMT3 Homolog 2
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途径
- Methionine Biosynthetic Process
抗原
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