LKB1 蛋白
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北京 101111
Quick Overview for LKB1 蛋白 (ABIN7939544)
抗原
See all LKB1 (STK11) 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant STK11 / LKB1 protein
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serine/threonine Kinase 11 (STK11) (AA 1-433) protein (GST tag)
STK11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
serine/threonine Kinase 11 (STK11) (AA 30-152) protein (His-IF2DI Tag)STK11 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
serine/threonine Kinase 11 (STK11) (AA 1-429), (partial) protein (His-SUMO Tag)STK11 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant STK11 / LKB1 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- LKB1 (STK11) (serine/threonine Kinase 11 (STK11))
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别名
- STK11 & LKB1
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背景
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Protein Background: STK11 (Serine/Threonine Kinase 11) is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members and plays a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 phosphorylates the T-loop of AMPK family proteins, thus promoting their activity. STK11 phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK and also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. STK11 acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage.
Short Description: Recombinant STK11 / LKB1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_000446.1) with an N-terminal FLAG tag. The molecular weight of the protein is 49.6 kDa.
Aliases: Serine / threonine kinase 11
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途径
- AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
抗原
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