RNF4 蛋白
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北京 101111
Quick Overview for RNF4 蛋白 (ABIN7939519)
抗原
See all RNF4 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant RNF4 protein
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Ring Finger Protein 4 (RNF4) (AA 1-190) protein (GST tag)
RNF4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Ring Finger Protein 4 (RNF4) (AA 1-190) protein (His tag)RNF4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Ring Finger Protein 4 (RNF4) proteinRNF4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant WB, SDS, ELISA, IP
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant RNF4 protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RNF4 (Ring Finger Protein 4 (RNF4))
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别名
- RNF4
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背景
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Protein Background: RNF4 (E3 ubiquitin-protein ligase RNF4) also known as RES4-26, SLX5 and SNURF. RNF4 is a E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'- , 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
Short Description: Recombinant RNF4 protein that includes full length of human RNF4 protein (accession number NP_001171938.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 23.48 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: E3 ubiquitin-protein ligase RNF4, RES4-26, SLX5, SNURF
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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