PKN2 蛋白
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Quick Overview for PKN2 蛋白 (ABIN7939478)
抗原
See all PKN2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant PKN2 protein
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Protein Kinase N2 (PKN2) protein (Myc-DYKDDDDK Tag)
PKN2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PKN2 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PKN2 (Protein Kinase N2 (PKN2))
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别名
- PKN2
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背景
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Protein Background: PKN2 (Protein Kinase N2), a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. PKN2 plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. This protein phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin and phosphorylates HDAC5, therefore lead to impair HDAC5 import. PKN2 is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It also stimulates FYN kinase activity which is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. PKN2 regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion and inhibits Akt pro-survival-induced kinase activity.
Short Description: Recombinant PKN2 protein was expressed in baculovirus expression system as the full length protein (accession number NP_001307638.1) with a N-terminal FLAG tag. The molecular weight of the protein is 111.6 kDa.
Aliases: Protein Kinase N2
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途径
- Cell-Cell Junction Organization
抗原
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