PKC eta 蛋白
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Quick Overview for PKC eta 蛋白 (ABIN7939470)
抗原
See all PKC eta (PRKCH) 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant PRKCH protein
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Protein Kinase C, eta (PRKCH) (AA 1-683) protein (His tag)
custom-made PRKCH 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Protein Kinase C, eta (PRKCH) (AA 1-41) protein (GST tag)PRKCH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein Kinase C, eta (PRKCH) (AA 614-674) protein (His tag)PRKCH 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PRKCH protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))
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别名
- PRKCH
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背景
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Protein Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PRKCH (Protein Kinase C Eta), a calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. PRKCH can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). Diseases associated with PRKCH include Stroke, Ischemic and Glioblastoma.
Short Description: Recombinant PRKCH protein was expressed in baculovirus expression system as the full length protein (accession number NP_006246.2) with a N-terminal FLAG tag. The molecular weight of the protein is 79.1 kDa.
Aliases: Protein Kinase C Eta, PKC Eta
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途径
- Myometrial Relaxation and Contraction, Thromboxane A2 Receptor Signaling
抗原
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