PLK3 Protein (AA 57-340)
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Quick Overview for PLK3 Protein (AA 57-340) (ABIN7939428)
抗原
See all PLK3 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 57-340
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原理
- Recombinant PLK3 (57-340) protein
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Polo-Like Kinase 3 (PLK3) (AA 1-646) protein (GST tag)
PLK3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PLK3 (57-340) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PLK3 (Polo-Like Kinase 3 (PLK3))
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别名
- PLK3
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背景
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Protein Background: PLK3 (Polo Like Kinase 3) is a serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly and phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/ TP53, p73/TP73, PTEN, TOP2A and VRK1. PLK3 phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis and plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. PLK3 involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73 and phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53- mediated apoptosis and phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. It phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions and phosphorylates HIF1A and JUN is response to hypoxia and phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Diseases associated with PLK3 include Breast Cancer.
Short Description: Recombinant PLK3 (57-340) protein that includes amino acids 57-340 of human PLK3 protein (accession number NP_004064.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 33.7 kDa.
Aliases: Polo Like Kinase 3
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途径
- Regulation of long-term Neuronal Synaptic Plasticity
抗原
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