NAT10 蛋白
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北京 101111
Quick Overview for NAT10 蛋白 (ABIN7939363)
抗原
See all NAT10 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant NAT10 protein
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N-Acetyltransferase 10 (GCN5-Related) (NAT10) (AA 1-1025) protein (GST tag)
NAT10 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
N-Acetyltransferase 10 (GCN5-Related) (NAT10) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NAT10 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant NAT10 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))
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别名
- NAT10
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背景
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Protein Background: NAT10 (N-Acetyltransferase 10) is a RNA cytidine acetyltransferase that catalyzes the formation of N(4)- acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs and mediates the formation of ac4C at position 1842 in 18S rRNA. NAT10 requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, NAT10 is also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. It activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. NAT10 involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.
Short Description: Recombinant NAT10 protein was expressed in baculovirus expression system as the full length protein (accession number NP_078938.3)) with a N-terminal FLAG tag. The molecular weight of the protein is 117 kDa.
Aliases: N-Acetyltransferase 10
抗原
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