MAP3K8 Protein (AA 30-397)
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Quick Overview for MAP3K8 Protein (AA 30-397) (ABIN7939340)
抗原
See all MAP3K8 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 30-397
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原理
- Recombinant MAP3K8 (30-397) / COT protein
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 106,314.67 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 152,621.24 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 1-467) protein (His tag)
custom-made MAP3K8 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 1-467) protein (His tag)custom-made MAP3K8 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 1-467) protein (GST tag)MAP3K8 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) protein (GST tag)MAP3K8 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 91 % as determined by reducing SDS-PAGE.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant MAP3K8 / COT (30-397) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
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别名
- MAP3K8 & COT
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背景
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Protein Background: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8) is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. It also involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells and involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro>, MAP3K8 activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner and leading to up-regulation of IL8 and CCL4 and transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages. Thus MAP3K8 may play a role in the regulation of immunoglobulin production and may also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, MAP3K8 activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF.
Short Description: Recombinant MAP3K8 / COT (30-397) protein that includes amino acids 30-397 of human MAP3K8 protein (accession number NP_001231063.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 42.8 kDa.
Aliases: (Mitogen-Activated Protein Kinase Kinase Kinase 8
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途径
- PI3K-Akt Signaling, TCR Signaling
抗原
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