MBD2 Protein (Methyl-CpG-binding domain)
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Quick Overview for MBD2 Protein (Methyl-CpG-binding domain) (ABIN7939274)
抗原
See all MBD2 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- Methyl-CpG-binding domain
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原理
- Recombinant MBD2-MBD protein
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant MBD2-MBD protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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别名
- MBD2
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背景
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Protein Background: MBD2 (Methyl-CpG-binding domain protein 2)is a transcriptional repressor that Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Also binds hemimethylated DNA as well and recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Short Description: Recombinant MBD2-MBD protein that includes amino acids 140-219 of human MBD2 protein (accession number NP_003918.1) was expressed in E. coli cells with an N-terminal 6xHis tag. The molecular weight of the protein is 11.19 kDa.
Aliases: Methyl-CpG -binding domain protein 2, CXXC3, PCM1, Protein Containing Methyl-CpG Binding Domain 1
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途径
- Chromatin Binding
抗原
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