MBD1 Protein (Methyl-CpG-binding domain)
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Quick Overview for MBD1 Protein (Methyl-CpG-binding domain) (ABIN7939271)
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See all MBD1 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- Methyl-CpG-binding domain
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原理
- Recombinant MBD1-MBD protein
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Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 1-605) protein (GST tag)
MBD1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant MBD1-MBD protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
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别名
- MBD1
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背景
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Protein Background: MBD1 (Methyl-CpG-binding domain protein 1) is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Short Description: Recombinant MBD1-MBD protein that includes amino acids 1-70 of human MBD1 protein (accession number NP_056671.2) was expressed in E. coli cells with an N-terminal 6xHis tag. The molecular weight of the protein is 10.11 kDa.
Aliases: Methyl-CpG-binding domain protein 1, CXXC3, PCM1, Protein Containing Methyl-CpG-Binding Domain 1
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