KAT6B Protein (AA 718-1008, full length)
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北京 101111
Quick Overview for KAT6B Protein (AA 718-1008, full length) (ABIN7939228)
抗原
蛋白类型
宿主
资源
应用范围
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产品特性
- AA 718-1008, full length
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原理
- Recombinant KAT6B / MORF (718-1008) protein
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产品特性
- KAT6B (Lysine Acetyltransferase 6B), also called as MOZ2, MORF or MYST4, is a histone acetyltransferase and component of the MOZ/MORF protein complex. It has a histone H3 acetyltransferase activity. In addition to its acetyltransferase activity, the encoded full length protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. So it may be involved in both positive and negative regulation of transcription. KAT6B is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of KAT6B gene and the CREBBP gene results in acute myeloid leukemias. It may also be involved in cerebral cortex development.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant KAT6B / MORF (718-1008) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- KAT6B (K(lysine) Acetyltransferase 6B (KAT6B))
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别名
- KAT6B & MORF
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背景
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Protein Background: KAT6B (Lysine Acetyltransferase 6B), also called as MOZ2, MORF or MYST4, is a histone acetyltransferase and component of the MOZ/MORF protein complex. It has a histone H3 acetyltransferase activity. In addition to its acetyltransferase activity, the encoded full length protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. So it may be involved in both positive and negative regulation of transcription. KAT6B is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of KAT6B gene and the CREBBP gene results in acute myeloid leukemias. It may also be involved in cerebral cortex development.
Short Description: Recombinant KAT6B / MORF (718-1008) protein that includes amino acids 718-1008 of human KAT6B protein (accession number NP_036462.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 35.7 kDa. This product is the catalytic domain of KAT6B protein.
Aliases: MYST4, Lysine Acetyltransferase 6B
抗原
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