HIPK3 Protein (AA 163-562)
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Quick Overview for HIPK3 Protein (AA 163-562) (ABIN7939163)
抗原
See all HIPK3 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 163-562
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原理
- Recombinant HIPK3 (163-562) protein
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant HIPK3 (163-562) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))
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别名
- HIPK3
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背景
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Protein Background: HIPK3 (Homeodomain Interacting Protein Kinase 3), also known as FIST. It is a serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression, HIPK3 phosphorylates JUN and RUNX2. It seems to negatively regulate apoptosis by promoting FADD phosphorylation and enhances androgen receptormediated transcription. It may also act as a transcriptional co-repressor for NK homeodomain transcription factors. In osteoblasts, HIPK3 supports transcription activation and phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2 mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Short Description: Recombinant HIPK3 (163-562) protein that includes amino acids 163-562 of human HIPK3 protein (accession number NP_005725.3) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 46.6 kDa.
Aliases: Homeodomain Interacting Protein Kinase 3, DYRK6, FIST3, YAK1
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