HIPK2 Protein (AA 1-640)
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Quick Overview for HIPK2 Protein (AA 1-640) (ABIN7939161)
抗原
See all HIPK2 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 1-640
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原理
- Recombinant HIPK2 (1-640) protein
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Homeodomain Interacting Protein Kinase 2 (HIPK2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)
HIPK2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant HIPK2 (1-640) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 500 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))
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别名
- HIPK2
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背景
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Protein Background: HIPK2 (Homeodomain Interacting Protein Kinase 2) is a conserved serine/threonine kinase that involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. It acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. HIPK2 phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. It inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation), the phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex.
Short Description: Recombinant HIPK2 (1-640) protein that includes amino acids 1-640 of human HIPK2 protein (accession number NP_001106710.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 69.5 kDa.
Aliases: PRO0593
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途径
- Cell Division Cycle
抗原
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