EIF4A2 蛋白
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Quick Overview for EIF4A2 蛋白 (ABIN7938832)
抗原
See all EIF4A2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant EIF4A2 protein
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产品特性
- EIF4A2 (Eukaryotic Translation Initiation Factor 4A, Isoform 2), also called EIF4F or DDX2B, is an ATP dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition. It is required for mRNA binding to the ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. This protein is involved in the binding of mRNA to 40S subunit of ribosome, ubiquitous with high expression in skeletal muscle and ovary. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are the TGFb pathway and Apoptotic pathways in Synovial Fibroblasts.
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Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) (AA 1-100) protein (GST tag)
EIF4A2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) (AA 1-84) protein (His-IF2DI Tag)EIF4A2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) protein (Myc-DYKDDDDK Tag)EIF4A2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) (AA 1-407), (full length) protein (GST tag)EIF4A2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95 % WB, SDS, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant EIF4A2 protein is supplied in 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 10 % glycerol, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- EIF4A2 (Eukaryotic Translation Initiation Factor 4A2 (EIF4A2))
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别名
- EIF4A2
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背景
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Protein Background: EIF4A2 (Eukaryotic Translation Initiation Factor 4A, Isoform 2), also called EIF4F or DDX2B, is an ATP dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition. It is required for mRNA binding to the ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. This protein is involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle and ovary. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are the TGFb pathway and Apoptotic pathways in Synovial Fibroblasts.
Short Description: Recombinant EIF4A2 protein was expressed in E.coli as the full length protein (accession number NP_001958.2) with an N-terminal 6xHis Tag. The molecular weight of the protein is 49.9 kDa.
Aliases: Eukaryotic Translation Initiation Factor 4A2, DDX2B
抗原
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