CDKN2C 蛋白
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北京 101111
Quick Overview for CDKN2C 蛋白 (ABIN7938744)
抗原
See all CDKN2C 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant CDKN2C protein
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) (AA 1-168) protein (His tag)
custom-made CDKN2C 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) (AA 1-168) protein (His tag)custom-made CDKN2C 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) (AA 1-168) protein (GST tag)CDKN2C 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C) (AA 1-168) protein (His-IF2DI Tag)CDKN2C 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant CDKN2C protein is supplied in 25 mM Tris pH 7.4, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))
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别名
- CDKN2C
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背景
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Protein Background: CDKN2C (Cyclin-dependent kinase 4 inhibitor C,also known as Cyclin-dependent kinase 6 inhibitor,p18- INK4c or p18-INK6) is a cyclin kinase inhibitors. Cell cycle regulatory proteins play a critical role in both normal cell growth and tumorigenesis, and the cyclin dependent kinases (CDKs) are the principle regulators of cell cycle progression , and thus are important candidates for therapeutic tumour suppressors. The CDKs, which are responsible for the phosphorylation of the retinoblastoma protein (pRb) and pRb related proteins, are in turn regulated by changes in cyclin levels, phosphorylation and the presence of cyclin kinase inhibitors (CKIs). Two classes of CKIs are present within mammalian cells . One class, the p21 family, consists of p21CIP1/WAF1, p27KIP1 and p57KIP2 which are general inhibitors of the G1S CDKs. Homology between family members is limited to a conserved amino-terminal 60-residue domain responsible for kinase binding and inhibition. The second class of CKIs, the INK4 (Inhibitor of CDK4) family is a group of ankyrin repeat proteins whose members p16INK4a, p15INK4b, p18INK4c and p19INK4d are specific inhibitors of cyclin D1/CDK4 or CDK6 complexes.CDKN2C/p18INK4c as a cyclin kinase inhibitors,Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Short Description: Recombinant CDKN2C protein was expressed in E.colias the full length protein (accession number NP_001253.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 20.06 kDa.
Aliases: Cyclin-dependent kinase 4 inhibitor C,also known as Cyclin-dependent kinase 6 inhibitor,p18- INK4c or p18-INK6
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
抗原
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