CRTC2 蛋白
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北京 101111
Quick Overview for CRTC2 蛋白 (ABIN7938730)
抗原
See all CRTC2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant CRTC2 protein
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CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 1-693) protein (GST tag)
CRTC2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant CRTC2 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
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别名
- CRTC2
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背景
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Protein Background: CRTC2 as a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Short Description: Recombinant CRTC2 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_859066.1) with an N-terminal FLAG tag. The molecular weight of CRTC2 is 74.57 kDa.
Aliases: TORC2, CREB-Regulated Transcription Coactivator 2
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途径
- AMPK Signaling, Carbohydrate Homeostasis
抗原
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