CDC42BPA Protein (AA 1-473)
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Quick Overview for CDC42BPA Protein (AA 1-473) (ABIN7938683)
抗原
See all CDC42BPA 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 1-473
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原理
- Recombinant MRCKa / CDC42BPA (1-473) protein
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant MRCKa / CDC42BPA (1-473) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CDC42BPA (CDC42 Binding Protein Kinase alpha (DMPK-Like) (CDC42BPA))
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别名
- MRCKa & CDC42BPA
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背景
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Protein Background: CDC42BPA (CDC42 Binding Protein Kinase Alpha) is a serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. This protein regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, CDC42BPA is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. In concert with FAM89B/LRAP25 CDC42BPA mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Short Description: Recombinant MRCKa / CDC42BPA (1-473) protein that includes amino acids 1-473 of human MRCKa protein (accession number NP_001352948.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 55.7 kDa.
Aliases: CDC42 Binding Protein Kinase Alpha
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