beta Catenin 蛋白
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北京 101111
Quick Overview for beta Catenin 蛋白 (ABIN7938678)
抗原
See all beta Catenin (CATNB) 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant beta-Catenin protein
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant beta-Catenin protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- beta-Catenin
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背景
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Protein Background: beta-Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.
Short Description: Recombinant beta-Catenin protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001091679.1) with an N-terminal FLAG tag. The molecular weight of beta-Catenin is 86.79 kDa.
Aliases: CTNNB1, catenin beta 1, armadillo, CTNNB, NEDSDV, MRD19, EVR7
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途径
- Peptide Hormone Metabolism
抗原
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