CTBP2 蛋白
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北京 101111
Quick Overview for CTBP2 蛋白 (ABIN7938670)
抗原
See all CTBP2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant CTBP2 protein
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产品特性
- CTBP2 (C-Terminal Binding Protein 2), also written as CtBP2, is a protein that binds to the C-terminus of adenovirus E1A proteins. It ubiquitously expresses with 2 higher level in heart, skeletal muscle, pancreas, associating to adenovirus E1A,C terminal proteins, involved with histone deacetylase and E2F3 in transcription repression. CTBP2 is a corepressor targeting diverse transcription regulators. It functions in brown adipose tissue (BAT) differentiation (By similarity). CTBP1 gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. This product is isoform 1. CTBP2 and another C-Terminal Binding Protein, CTBP1 can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.
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C-terminal Binding Protein 2 (CTBP2) (AA 1-445) protein (GST tag)
CTBP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
C-terminal Binding Protein 2 (CTBP2) (AA 301-445) protein (His tag)CTBP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
C-terminal Binding Protein 2 (CTBP2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)CTBP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
C-terminal Binding Protein 2 (CTBP2) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)CTBP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant CTBP2 protein is supplied in 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 10 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CTBP2 (C-terminal Binding Protein 2 (CTBP2))
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别名
- CTBP2
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背景
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Protein Background: CTBP2 (C-Terminal Binding Protein 2), also written as CtBP2, is a protein that binds to the C-terminus of adenovirus E1A proteins. It ubiquitously expresses with 2 higher level in heart, skeletal muscle, pancreas, associating to adenovirus E1A, C terminal proteins, involved with histone deacetylase and E2F3 in transcription repression. CTBP2 is a corepressor targeting diverse transcription regulators. It functions in brown adipose tissue (BAT) differentiation (By similarity). CTBP1 gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. This product is isoform 1. CTBP2 and another C-Terminal Binding Protein, CTBP1 can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.
Short Description: Recombinant CTBP2 protein was expressed in E.coli as the full length protein (accession number NP_001320.1) with an N-terminal 6xHis Tag. The molecular weight of the protein is 52.5 kDa.
Aliases: C-terminal binding protein 2
抗原
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