Aurora Kinase B Protein (AURKB)
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Quick Overview for Aurora Kinase B Protein (AURKB) (ABIN7938612)
抗原
See all Aurora Kinase B (AURKB) 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant AURKB protein
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Aurora Kinase B (AURKB) (AA 1-344) protein (GST tag)
AURKB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Aurora Kinase B (AURKB) (AA 1-90) protein (GST tag)AURKB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Aurora Kinase B (AURKB) (AA 1-344) protein (His tag)AURKB 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant AURKB protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- Aurora Kinase B (AURKB)
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别名
- AURKB
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背景
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Protein Background: AURKB (Aurora Kinase B) is a member of the aurora kinase subfamily of serine/threonine kinases and phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. The CPC complex acts as a key regulator of mitosis. which has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatininduced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/ vimentin, HASPIN, and histone H3. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1.
Short Description: Recombinant AURKB protein was expressed in baculovirus expression system as the full length protein (accession number AAC12709.1) with a N-terminal FLAG tag. The molecular weight of the protein is 40.5 kDa.
Aliases: Aurora kinase B
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途径
- TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades
抗原
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