Arc 蛋白
Our Local Distributor
北京 101111
Quick Overview for Arc 蛋白 (ABIN7938569)
抗原
See all Arc 蛋白蛋白类型
宿主
资源
应用范围
-
-
原理
- Recombinant ARC protein
-
-
想要此Protein的其他选项吗？
!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
-
Activity-Regulated Cytoskeleton-Associated Protein (Arc) (AA 1-396) protein (GST tag)
Arc 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Activity-Regulated Cytoskeleton-Associated Protein (Arc) (AA 1-396) protein (His-IF2DI Tag)Arc 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Activity-Regulated Cytoskeleton-Associated Protein (Arc) (Arg3) protein (Myc-DYKDDDDK Tag)Arc 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Recombinant ARC protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
-
注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
-
储存条件
- -80 °C
-
储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
-
-
- Arc (Activity-Regulated Cytoskeleton-Associated Protein (Arc))
-
别名
- ARC
-
背景
-
Protein Background: ARC (Activity-regulated cytoskeleton-associated protein) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1.In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
Short Description: Recombinant ARC protein that includes full length of the human ARC protein (accession number NP_056008.1) was expressed in E. coli cells with an N-terminal His tag with an observed molecular weight of 47.48 kDa.
Aliases: Activity-regulated cytoskeleton-Associated protein, KIAA0278, ARC, ARG3.1, HArc, ARG3.1
抗原
-
