FAM131B-BRAF (Active) protein (GST tag)
This Recombinant FAM131B-BRAF protein is expressed in Baculovirus infected Insect Cells.
产品编号 ABIN7856311
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for FAM131B-BRAF (Active) protein (GST tag) (ABIN7856311)
抗原
FAM131B-BRAF
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
Baculovirus infected Insect Cells
应用范围
Kinase Activity Assay (KAA)
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标记
- GST tag
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原理
- Recombinant FAM131B-BRAF (Fex2Bex9), Active
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序列
- FAB131B (1-30 exon2)-BRAF (381-end or exon9-18)
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产品特性
- Recombinant human fusion FAB131B (1-30 exon2)-BRAF (381-end or exon9-18) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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过滤
- Sterile
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25-1.0 mM DTT, 0-0.1 mM PMSF, 10-25 % glycerol
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储存液
- Dithiothreitol (DTT), PMSF
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -80 °C
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储存方法
- Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.
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有效期
- 12 months
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- FAM131B-BRAF
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Sub Type
- Fusionprotein
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背景
- KIAA1549-BRAF is a gene fusion resulting from a tandem duplication event involving the BRAF kinase gene that have recently been identified as the most frequent genetic alteration in many cancers. The KIAA1549-BRAF fusion typically results from a 2.0 Mb tandem duplication in chromosome band 7q34. The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma and many other pediatric brain neoplasms. KIAA1549-BRAF fusion gene and BRAF (V600E) mutation may be responsible for deregulation of the Ras-RAF-ERK signaling pathway in many brain cancers.
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分子量
- ~75 kDa
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NCBI登录号
- NM_004333
抗原
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