EML4-ALK (Active) protein (GST tag)
This Recombinant EML4-ALK protein is expressed in Baculovirus infected Insect Cells.
产品编号 ABIN7856245
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for EML4-ALK (Active) protein (GST tag) (ABIN7856245)
抗原
EML4-ALK
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
Baculovirus infected Insect Cells
应用范围
Kinase Activity Assay (KAA)
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标记
- GST tag
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原理
- Recombinant EML4-ALK (Eex14Aex20), Active
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序列
- EML4 (1-534) - ALK (1058-end)
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产品特性
- Recombinant human fusion protein EML4 (1-534a.a., exons1-14) - ALK (1058-end, exons20-29) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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过滤
- Sterile
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25-1.0 mM DTT, 0-0.1 mM PMSF, 10-25 % glycerol
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储存液
- Dithiothreitol (DTT), PMSF
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -80 °C
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储存方法
- Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.
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有效期
- 12 months
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- EML4-ALK
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Sub Type
- Fusionprotein
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背景
- ALK or CD246 is a receptor tyrosine kinase, which belongs to the insulin receptor superfamily which comprises an extracellular domain, a hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. CD246 plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. ALK-positive neoplasms represent a distinct entity because the morphology of the tumors is often neither anaplastic nor large cell and the tumors should be referred to as ALK lymphomas. CD246 has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. EML4-ALK mutations in lung cancer confer resistance to ALK inhibitors.
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分子量
- ~152 kDa
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NCBI登录号
- NM_019063, NM_004304
抗原
-
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