IL-13 蛋白
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北京 101111
Quick Overview for IL-13 蛋白 (ABIN7849723)
抗原
See all IL-13 (IL13) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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原理
- Recombinant Human IL-13 Protein
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过滤
- 0.2 μm filtered
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内毒素水平
- <0.01 EU/μg by LAL test
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Dissolve the lyophilized protein in distilled water(It is not recommended to reconstitute to a concentration<100 μg/mL.)
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Ship at 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
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- IL-13 (IL13) (Interleukin 13 (IL13))
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别名
- IL-13
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背景
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Synonyms: IL13, IL-13, P600, interleukin 13
Description: Recombinant human IL-13 is produced by the mammalian system, with the target gene encoding Gly35-Asn146 expressed with 6x His-tag at the C-terminus.
Background: Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene.IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb.It has a mass of 13 kDa and folds into 4 alpha helical bundles.The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4), however it only has 25 % sequence identity to IL-4 and is capable of IL-4 independent signaling.IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes.Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation.It is a mediator of allergic inflammation and different diseases including asthma,and atopic dermatitis.
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途径
- JAK/STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
抗原
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