Creatine Kinase MB Protein (CKM)
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Quick Overview for Creatine Kinase MB Protein (CKM) (ABIN7849673)
抗原
蛋白类型
宿主
资源
应用范围
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原理
- Native Human Creatine kinase MB,CK-MB protein
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 20 mM Tris-HCl pH 8.0, 5 mM beta Mercaptoethano and 6 % Sugrose.
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储存条件
- 4 °C,-20 °C
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储存方法
- Ship at 4°C.Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
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- Creatine Kinase MB (CKM)
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别名
- Creatine kinase MB
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背景
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Synonyms: CK-MB, B-CK, brain creatine kinase, CKBB, CKMB, CKMM, creatine kinase B, creatine kinase brain, creatine kinase M, Creatine kinase MB, Creatine Kinase MB type, creatine kinase muscle, M-CK, creatine kinase-M/B, KCRB_HUMAN, muscle creatine kinase
Description: Purified Creatine Kinase-MB Isoenzyme Protein.
Background: Creatine kinase isoenzyme-MB (CK-MB) is a biomarker for detecting myocardial injury. It is a simple, widely available, and useful biomarker for predicting adverse in-hospital clinical outcomes in pulmonary embolism. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The CK-MB-to-total-CK ratio is an easily available indicator and could be clinically utilized as a primary screening tool for cancer. Higher ratio of CK-MB-to-total-CK was specifically associated with certain malignancies, like colorectal cancer, lung cancer and hepatocellular carcinoma, as well as some cancer-associated status factors such as advanced stage and liver metastasis.
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