SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (AA 910-988)
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Quick Overview for SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (AA 910-988) (ABIN7669678)
抗原
See all SARS-CoV-2 Spike (SARS-CoV-2 S) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 910-988
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原理
- Recombinant SARS-CoV-2 S Protein HR1
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序列
- Gly910-Glu988
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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SARS-CoV-2 Spike (SARS-CoV-2 S) (Super Stable Trimer) protein (His tag)
SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 16-1188), (Trimer) (Active) protein (His-Avi Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.1.7 - alpha), (RBD) protein (Fc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (RBD) protein (His tag,mFc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.617.2 - delta), (RBD) protein (Fc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.1.529 - Omicron), (RBD) (Active) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-532), (RBD) (Active) protein (His-Avi Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (E484K), (K417N), (N501Y), (RBD) (Active) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
SARS-CoV-2 Spike (SARS-CoV-2 S) (Super Stable Trimer) protein (His tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
SARS-CoV-2 Spike (SARS-CoV-2 S) (AA 319-541), (B.1.351 - beta), (RBD) protein (Fc Tag)SARS-CoV-2 S 宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. IA, AM, ADA, ScA
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- SARS-CoV-2 Spike (SARS-CoV-2 S)
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别名
- SARS-CoV-2 S
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物质类
- Viral Protein
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背景
- SARS-CoV-2 Spike,SARS-CoV-2 Spike Protein,The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
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分子量
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Calculated MW: 8.4 kDa
Observed MW: 8 kDa
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基因ID
- 43740568
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UniProt
- P0DTC2
抗原
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