S100P 蛋白
Quick Overview for S100P 蛋白 (ABIN7669564)
抗原
See all S100P 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human S100P/S100E Protein
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序列
- Met 1-Lys 95
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纯化方法
- > 97 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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S100 Calcium Binding Protein P (S100P) (AA 1-95) protein (His tag)
custom-made S100P 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
S100 Calcium Binding Protein P (S100P) (AA 1-69) protein (GST tag)S100P 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S100 Calcium Binding Protein P (S100P) (AA 1-95) protein (GST tag)S100P 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S100 Calcium Binding Protein P (S100P) protein (Myc-DYKDDDDK Tag)S100P 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- S100P (S100 Calcium Binding Protein P (S100P))
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别名
- S100P
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背景
- Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein which belongs to theS-100 family. S100P / S100E contains twoEF-hand domains. S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S100P / S100E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S100P / S100E may directly confer resistance to chemotherapy. S100P / S100E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S100P / S100E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S100P / S100E may provide a novel approach for treatment of pancreatic cancer. S100P / S100E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.,MIG9,Protein S100-E,Protein S100-P,S100 Calcium-Binding Protein P,S100E,S100P
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分子量
- 10.4 kDa
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UniProt
- P25815
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途径
- Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins
抗原
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