IL-31 Protein (His tag)
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Quick Overview for IL-31 Protein (His tag) (ABIN7669110)
抗原
See all IL-31 (IL31) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This IL-31 protein is labelled with His tag.
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原理
- Recombinant Mouse IL-31 protein(N-His)
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序列
- Thr 24-Cys 163
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纯化方法
- > 95 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 0.1 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Interleukin 31 (IL31) (AA 27-163) (Active) protein (His tag)
IL31 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Interleukin 31 (IL31) (AA 24-164) protein (Fc Tag)IL31 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interleukin 31 (IL31) (AA 24-163) protein (His tag)IL31 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 31 (IL31) (AA 24-159) protein (His tag)IL31 宿主: 犬 宿主: Baculovirus infected Insect Cells Recombinant > 95 % SDS
Interleukin 31 (IL31) (AA 24-164) (Active) protein (His tag)IL31 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 31 (IL31) proteinIL31 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 97,00% SDS
Interleukin 31 (IL31) proteinIL31 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 97,00% SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- IL-31 (IL31) (Interleukin 31 (IL31))
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别名
- IL-31
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背景
- C87042,Il31,Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24 % sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
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分子量
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Calculated MW: 16.6 kDa
Observed MW: 17 kDa
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UniProt
- Q6EAL8
抗原
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