FIL1d Protein (AA 2-155)
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北京 101111
Quick Overview for FIL1d Protein (AA 2-155) (ABIN7668988)
抗原
See all FIL1d 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 2-155
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原理
- Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5
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序列
- Val2-Asp155
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纯化方法
- > 95 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to inhibit IL-36 alpha, IL-36 beta or IL-36 gamma-induced IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 23.14 ng/ml.
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Interleukin 1 delta (FIL1d) (Active) protein
FIL1d 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 1 delta (FIL1d) (AA 1-155) protein (His tag)FIL1d 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1 delta (FIL1d) (Active) proteinFIL1d 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % (SDS-PAGE) SDS Active
Interleukin 1 delta (FIL1d) (Transcript Variant 2) (Active) proteinFIL1d 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- FIL1d (Interleukin 1 delta (FIL1d))
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别名
- IL-36RN,IL-1F5
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背景
- Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90 % sequence identity.,FIL,UNQ,PRO,IL1F,IL1L,IL1HY,IL1RP,PSORS,IL36RN,FIL1,FIL1(DELTA),FIL1D,IL-36Ra,IL1F5,IL1HY1,IL1L1,IL1RP3,IL36RA,PSORP,PSORS14,UNQ1896,PRO4342,FIL1 Delta,IL-1 Delta,IL-1F5,IL-1HY1,IL-1L1,IL-1ra Homolog 1,IL-1-Related Protein 3,IL-1RP3,Interleukin-1 Delta,Interleukin-1 Family Member 5,Interleukin-1 HY1,Interleukin-1 Receptor Antagonist Homolog 1,Interleukin-1-Like Protein 1,Interleukin-36 Receptor Antagonist Protein
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分子量
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calculated_mw: 16.8 kDa
observed_mw: 17 kDa
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UniProt
- Q9UBH0
抗原
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