HIST3H2A 蛋白
This Recombinant HIST3H2A protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7668900
发货至:
中国
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Quick Overview for HIST3H2A 蛋白 (ABIN7668900)
抗原
See all HIST3H2A 蛋白
HIST3H2A
(Histone H2A Type 3 (HIST3H2A))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 90 % as determined by reducing SDS-PAGE.
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原理
- Recombinant Human HIST3H2A/Histone H2A Protein
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序列
- Met 1-Lys 130
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纯化方法
- > 90 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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Histone H2A Type 3 (HIST3H2A) protein (Myc-DYKDDDDK Tag)
HIST3H2A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM β-Mercaptoethanol, pH 6.9
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- HIST3H2A (Histone H2A Type 3 (HIST3H2A))
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别名
- HIST3H2A
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背景
- MGC3165,Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. However, extracellular histones are a double-edged sword because they also damage host tissue and may cause death. Histones bound to platelets, induced calcium influx, and recruited plasma adhesion proteins such as fibrinogen to induce platelet aggregation. Histone cluster 3, H2a also known as histone H2A (HIST3H2A) is a member of histones. Covalent modification of histones is important in regulating chromatin dynamics and transcription. One example of such modification is ubiquitination, which mainly occurs on histones H2A and H2B. E3 ubiquitin ligase complex is specific for histone H2A (HIST3H2A). Reducing the expression of Ring2 results in a dramatic decrease in the level of ubiquitinated H2A in HeLa cells. DNA damage induces monoubiquitylation of histone H2A (HIST3H2A) in the vicinity of DNA lesions.
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分子量
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Calculated MW: 14.2 kDa
Observed MW: 14.2 kDa
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基因ID
- 92815
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UniProt
- Q7L7L0
抗原
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