Fibronectin Protein (FN) (AA 607-1265) (His tag)
This Recombinant Fibronectin protein is expressed in HEK-293 Cells.
产品编号 ABIN7668779
发货至:
中国
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Quick Overview for Fibronectin Protein (FN) (AA 607-1265) (His tag) (ABIN7668779)
抗原
See all Fibronectin (FN) 蛋白
Fibronectin (FN)
蛋白类型
Recombinant
宿主
人
资源
HEK-293 Cells
应用范围
Immunogen (Imm)
纯度
> 95 % as determined by reducing SDS-PAGE.
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产品特性
- AA 607-1265
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标记
- This Fibronectin protein is labelled with His tag.
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原理
- Recombinant Human Fibronectin/FN Protein (His Tag)
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序列
- Ser607-Pro1265
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU/mg of the protein as determined by the LAL method
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Biological Activity Comment
- Not validated for activity
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Fibronectin (FN)
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别名
- Fibronectin,FN
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背景
- CIG,ED-B,FINC,FN,FN1,FNZ,Fibronectin,GFND,GFND2,LETS,MSF,Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. Each monomer of FN consists of three types of homologous repeating units, that is 12 type I repeats, two type II repeats and 15-17 type III repeats. The occurrence of multiple isoforms results from alternative mRNA splicing of the ED-A, ED-B and III-CS regions, and subsequent post-translational modification. As an ECM component and one of the primary cell adhesion molecules, Fibronectin can be a ligand for fibrin, heparin, chondroitin sulfate, collagen/gelatin, as well as many integrin receptors through which FN mediates the variety of cellular signaling pathways. The study of solid human tumors showed among the early signs of malignant transformation the fragmentation of pericellular FN, concommitent with the increase of its production by the peritumoral stroma. These results should encourage further investigations concerning the potential importance of Fn production and breakdown during cancer progression. FN1 expression has been described to increase significantly from the morula towards the early blastocyst stage, suggesting that FN1 may also be involved in early blastocyst formation.
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分子量
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Calculated MW: 72.4 kDa
Observed MW: 90 kDa
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基因ID
- 2335
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UniProt
- P02751
抗原
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