beta-2 Microglobulin Protein (His tag)
Quick Overview for beta-2 Microglobulin Protein (His tag) (ABIN7668229)
抗原
See all beta-2 Microglobulin (B2M) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This beta-2 Microglobulin protein is labelled with His tag.
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原理
- Recombinant Human Beta-2-Microglobulin/B2M Protein (HEK293 Cells, His Tag)
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序列
- Met 1-Met 119
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纯化方法
- > 97 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)
B2M 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)B2M 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) (Active) protein (His tag)B2M 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. ELISA, WB, SDS, Imm, AcA Active
beta-2-Microglobulin (B2M) (AA 1-119) protein (GST tag)B2M 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
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别名
- Beta-2-Microglobulin
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背景
- B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.,B2M;Beta-2-Microglobulin;β2-Microglobulin
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分子量
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calculated_mw: 13.5 kDa
observed_mw: 13.5 kDa
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UniProt
- P61769
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途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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