beta-2 Microglobulin Protein (His tag)
Quick Overview for beta-2 Microglobulin Protein (His tag) (ABIN7668228)
抗原
See all beta-2 Microglobulin (B2M) 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
标记
- This beta-2 Microglobulin protein is labelled with His tag.
-
原理
- Recombinant Human Beta-2-Microglobulin/B2M Protein (E.coli, His Tag)
-
序列
- Ile21-Met 119
-
纯化方法
- > 95 % as determined by reducing SDS-PAGE.
-
过滤
- 0.2 μm filtered
-
内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
-
-
beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)
B2M 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)B2M 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
beta-2-Microglobulin (B2M) (AA 21-119) (Active) protein (His tag)B2M 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. ELISA, WB, SDS, Imm, AcA Active
beta-2-Microglobulin (B2M) (AA 1-119) protein (GST tag)B2M 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
-
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
有效期
- 12 months
-
-
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
-
别名
- Beta-2-Microglobulin,B2M
-
背景
- β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.,B2M,Beta-2-Microglobulin,β2-Microglobulin
-
分子量
-
calculated_mw: 14.0 kDa
observed_mw: 14 kDa
-
UniProt
- P61769
-
途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
-
