AMH Protein (AA 447-554) (His-TRX)
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Quick Overview for AMH Protein (AA 447-554) (His-TRX) (ABIN7668182)
抗原
See all AMH 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 447-554
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标记
- This AMH protein is labelled with His-TRX.
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原理
- Recombinant Mouse AMH Protein (TRX,His Tag)
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序列
- Ser447-Val554
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纯化方法
- > 95 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 10 EU/mg of the protein as determined by the LAL method
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Biological Activity Comment
- Not validated for activity
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Anti-Mullerian Hormone (AMH) (AA 450-552) protein (His tag)
AMH 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Anti-Mullerian Hormone (AMH) protein (Myc-DYKDDDDK Tag)AMH 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- AMH (Anti-Mullerian Hormone (AMH))
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别名
- AMH
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背景
- Amh,Anti-Muellerian hormone,Muellerian-inhibiting factor,Muellerian-inhibiting substance,Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and this process involves the SOX9 transcription factor. AMH is widely used for assessing ovarian reserve, and it is particularly convenient, because it is thought to have minimal variability throughout the menstrual cycle. Fetal anti-Mullerian hormone (AMH) is responsible for normal male sexual differentiation, and circulating AMH is used as a marker of testicular tissue in newborns with disorders of sex development. Anti-Mullerian hormone (AMH) produced in the developing testis induces the regression of the Mullerian duct, which develops into the oviducts, uterus and upper vagina. As well as other hormone receptors, and a decreased ovarian cortex cell proliferation. These results help understand the inhibitory effects of AMH on follicular development.
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分子量
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Calculated MW: 31.8 kDa
Observed MW: 35 kDa
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基因ID
- 11705
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UniProt
- P27106
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途径
- Negative Regulation of Hormone Secretion
抗原
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