Adrenomedullin Protein (ADM) (AA 21-185) (His tag)
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Quick Overview for Adrenomedullin Protein (ADM) (AA 21-185) (His tag) (ABIN7668126)
抗原
See all Adrenomedullin (ADM) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 21-185
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标记
- This Adrenomedullin protein is labelled with His tag.
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原理
- Recombinant Rat Adrenomedullin/ADM Protein (His Tag)
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序列
- Thr21-Leu185
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纯化方法
- > 95 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 10 EU/mg of the protein as determined by the LAL method
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Biological Activity Comment
- Not validated for activity
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Adrenomedullin (ADM) (AA 1-185) protein (GST tag)
ADM 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Adrenomedullin (ADM) (AA 45-92) protein (His tag)ADM 宿主: 人 宿主: 酵母菌 Recombinant Greater than 85 % as determined by SDS-PAGE. SDS
Adrenomedullin (ADM) protein (Myc-DYKDDDDK Tag)ADM 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Adrenomedullin (ADM) proteinADM 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Adrenomedullin (ADM)
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别名
- Adrenomedullin,ADM
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物质类
- Hormone
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背景
- ADM precursor,Adrenomedullin,PAMP,Preproadrenomedullin,ProAM N terminal 20 peptide,ProAM N20,Adrenomedullin (ADM, also AM) is a secreted, monomeric, 6 kDa member of the Adrenomedullin family of molecules. It is widely expressed, being found in smooth muscle cells, endothelium, adrenal medulla chromaffin cells, fibroblasts and keratinocytes. ADM has multiple functions, including vasodilation, the maintenance of vascular integrity, and the suppression of inflammatory mediator secretion. The ADM preproprecursor is 185 amino acids (aa) in length. It contains a 21 aa signal sequence, a processed 20 aa peptide termed PAMP (aa 22-41), an N-terminal propeptide (aa 45-91), the ADM precursor (amidation is required for maturation) (aa 94 143), and a C-terminal propeptide (aa 150-185). The ADM precursor with a terminal Gly147 circulates naturally with bioactive, mature amidated ADM (aa 94 143).
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分子量
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Calculated MW: 18.0 kDa
Observed MW: 25 kDa
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基因ID
- 25026
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UniProt
- P43145
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途径
- Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation
抗原
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