CLDN18.2 protein (DYKDDDDK Tag,Strep Tag)
宿主: 人
宿主: HEK-293 Cells
Synthetic Nanodisc
cryo-EM, ELISA, Imm, PhD, SPR
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- 抗原
- CLDN18.2
- 蛋白类型
- Synthetic Nanodisc
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- DYKDDDDK Tag,Strep Tag
- 应用范围
- Cryogenic electron microscopy (cryo-EM), ELISA, Immunogen (Imm), Phage Display (PhD), Surface Plasmon Resonance (SPR)
- 原理
- Human CLDN18.2-Strep full length protein-synthetic nanodisc
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CLDN18.2 protein
宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
CLDN18.2 protein-VLP宿主: 人 宿主: HEK-293 Cells VLP
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- 说明
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Advantages:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Mammalian cell expression system ensures post- translational modifications
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- CLDN18.2
- 背景
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SFTA5, SFTPJ
A member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. - 分子量
- The human full length CLDN18.2-Strep Protein has a MW of 27.5 kDa
- UniProt
- P56856
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