alpha-Latrotoxin 蛋白
This Native alpha-Latrotoxin protein is expressed in Spider (Araneae).
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产品编号 ABIN7582344
发货至:
中国
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Quick Overview for alpha-Latrotoxin 蛋白 (ABIN7582344)
抗原
alpha-Latrotoxin
蛋白类型
Native
宿主
Latrodectus tredecimguttatus
资源
Spider (Araneae)
应用范围
Blocking Peptide (BP)
纯度
≥98 % (HPLC)
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原理
- An Inducer of Neurotransmitter Release
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特异性
- Toxin target: Neurexin-1, ADGRL1 (latrophilin-1/CIRL), and tyrosine-protein phosphatase S (PTPRS) receptors, Highly disulfide bridged protein Glycosylated
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产品特性
- An Inducer of Neurotransmitter Release
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应用备注
- Antigen Preadsorption Control: 150 pM - 1 nM
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. Soluble in water. Once dissolved in water, add an equal volume of glycerol. Do not shake or vortex. Avoid multiple freeze-thaw cycles to maintain biological activity.
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缓冲液
- Lyopholized in 20 mM KPO4 pH 6.8.
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储存条件
- 4 °C,-20 °C
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储存方法
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.
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- alpha-Latrotoxin
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背景
- α-Latrotoxin-Lt1a, α-LTX-Lt1a, α-LTX,α-Latrotoxin is a 130 kDa protein toxin from the black widow spider venom and is the only protein in the venom that affects mammals.1,2 Application of the toxin to presynaptic preparations induces, after a delay, a huge increase in spontaneous neurotransmitter release, which can be evaluated by measuring the post synaptic response in the form of miniature end plate potentials. This toxin is widely used to induce and study neurotransmitter release, but the molecular mechanism of its action is not fully determined.α-Latrotoxin is isolated according to a modified protocol as described by Frontali3 and Grasso4.
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分子量
- 130 kDa
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UniProt
- P23631
抗原
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