alpha-Latrotoxin (Active) 蛋白
This Native alpha-Latrotoxin protein is expressed in Latrodectus tredecimguttatus (Mediterranean black widow spider).
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产品编号 ABIN7887287
发货至:
中国
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Quick Overview for alpha-Latrotoxin (Active) 蛋白 (ABIN7887287)
抗原
alpha-Latrotoxin
蛋白类型
Native
生物活性
Active
宿主
Latrodectus tredecimguttatus
资源
Latrodectus tredecimguttatus (Mediterranean black widow spider)
纯度
≥97 %
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原理
- α-Latrotoxin
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特异性
- Toxin target: Neurexin-1, ADGRL1 (latrophilin-1/CIRL), and tyrosine-protein phosphatase S (PTPRS) receptors
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Biological Activity Comment
- α-Latrotoxin induces exhaustive neurotransmitter release from nerve terminals1. Indirectly activates the ERK MAP kinase pathway.
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应用备注
- Antigen Preadsorption Control: 150 pM - 1 nM
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. The lyophilized product may be difficult to visualize. Carefully add the solvent directly to the vial interior. Dissolve the material by gently tapping, tilting, or rolling the vial. Avoid vigorous shaking or vortexing Reconstitute in high-quality pure water or a conventional buffer (e.g., 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 0.1 mM CaCl₂, and 0.2 mM MgCl₂). Avoid multiple freeze-thaw cycles and maintain optimal biological activity.
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缓冲液
- Lyophilized from 20 mM KPO4 buffer, pH 6.8.
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注意事项
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. protect from moisture
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储存条件
- -20 °C
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储存方法
- The product is shipped as a lyophilized powder at room temperature. Upon receipt, store at -20°C and protect from moisture.
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- alpha-Latrotoxin
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背景
- A potent inducer of massive neurotransmitter release via presynaptic neurexin and latrophilin receptors
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分子量
- 130 kDa
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UniProt
- P23631
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CAS-编号
- 65988-34-3
抗原
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