Fasciclin-2 (FAS2) 蛋白
This Native Fasciclin-2 protein is expressed in Snake (Serpentes).
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产品编号 ABIN7821956
发货至:
中国
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Quick Overview for Fasciclin-2 (FAS2) 蛋白 (ABIN7821956)
抗原
Fasciclin-2 (FAS2)
蛋白类型
Native
宿主
Dendroaspis angusticeps
资源
Snake (Serpentes)
应用范围
Activity Assay (AcA), Blocking Peptide (BP)
纯度
≥99 % (HPLC)
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原理
- A Selective, Potent and Reversible Blocker of Acetylcholinesterase
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序列
- TMCYSHTTTS RAILTNCGEN SCYRKSRRHP PKMVLGRGCG CPPGDDNLEV KCCTSPDKCN Y-OH
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特异性
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Toxin target: Acetylcholinesterase (AChE),
Disulfide bonds between: Cys3-Cys22, Cys17-Cys39, Cys41-Cys52 and Cys53-Cys59 -
产品特性
- A Selective, Potent and Reversible Blocker of Acetylcholinesterase
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应用备注
- Antigen Preadsorption Control: 1 - 10 nM
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
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缓冲液
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
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储存条件
- 4 °C,-20 °C
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储存方法
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- Fasciclin-2 (FAS2)
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别名
- Fasciculin-II
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背景
- Fasciculin-2, Fas-2, Fas2, FAS-II, Toxin TA1, Acetylcholinesterase toxin F-VII, fasciculin, fasciculin II, fasciculin 2,Fasciculin-II is a 61 amino acid peptidyl toxin with four disulfide bonds, isolated from the Eastern green mamba (Dendroaspis angusticeps) venom. Fasciculin-II belongs to the three finger protein of Elapidae toxin family. Fasciculin-II differs from Fasciculin-I only at one position by a replacement of Tyr with Asp or Asn1.Fasciculin-II was shown to be a selective potent and reversible blocker of acetylcholinesterase by binding to the peripheral site of the enzyme1. Injection of Fasciculin-II to mice causes severe, generalized, and long-lasting twitching (fasciculation) due to its ability to prevent degradation and therefore promote acetylcholine accumulation at the neuromuscular junction2.
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分子量
- 6749.6 Da
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UniProt
- P0C1Z0
抗原
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