Dendrotoxin-I (Active) 蛋白
This Native Dendrotoxin-I protein is expressed in Dendroaspis polylepis polylepis (Black mamba snake).
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产品编号 ABIN7887260
发货至:
中国
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Quick Overview for Dendrotoxin-I (Active) 蛋白 (ABIN7887260)
抗原
Dendrotoxin-I
蛋白类型
Native
生物活性
Active
宿主
Dendroaspis polylepis
资源
Dendroaspis polylepis polylepis (Black mamba snake)
纯度
≥98 % (HPLC)
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原理
- Dendrotoxin-I
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序列
- QPLRKLCILH RNPGRCYQKI PAFYYNQKKK QCEGFTWSGC GGNSNRFKTI EECRRTCIRK -OH
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特异性
- Toxin target: KV1.1, KV1.2, KV1.6 voltage-gated potassium channels
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Biological Activity Comment
- Dendrotoxin-I is a highly selective blocker of voltage-gated K+ channels (KV1.1 and KV1.2), as well as heteromultimeric channels containing these, with other KV1 isoforms1. The inhibition effect is higher in Xenopus oocytes compared to mammalian cells2.
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应用备注
- Antigen Preadsorption Control: 10 - 100 nM
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial and dissolve by gently tapping, tilting, or rolling the vial. Avoid vigorous vortexing, a brief, light vortex of 1-2 seconds is acceptable if necessary. The product is readily soluble in high-quality pure water at micromolar to millimolar concentrations (typically 100 μM to 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x the final working concentration. Divide the stock solution into small, single-use aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh working solutions just before use. Avoid multiple freeze-thaw cycles to maintain optimal biological activity.
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缓冲液
- Lyophilized from double distilled water (ddH2O). May contain residual trifluoroacetate (TFA).
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注意事项
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom,Avoid multiple freeze-thaw cycles to maintain optimal biological activity,Avoid vigorous vortexing. protect from moisture
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储存条件
- -20 °C
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储存方法
- The product is shipped as a lyophilized powder at room temperature. Upon receipt, store at -20°C and protect from moisture.
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- Dendrotoxin-I
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背景
- A potent and selective blocker of neuronal KV1.1, KV1.2, KV1.6 potassium channels
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分子量
- 7149 Da
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UniProt
- P00979
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CAS-编号
- 107950-33-4
抗原
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