alpha-Dendrotoxin 蛋白
This Native alpha-Dendrotoxin protein is expressed in Snake (Serpentes).
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产品编号 ABIN7821944
发货至:
中国
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Quick Overview for alpha-Dendrotoxin 蛋白 (ABIN7821944)
抗原
alpha-Dendrotoxin
蛋白类型
Native
宿主
Dendroaspis angusticeps
资源
Snake (Serpentes)
应用范围
Blocking Peptide (BP)
纯度
≥98 % (HPLC)
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原理
- A Blocker of KV1.1, KV1.2, KV1.6 and ASIC Channels
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序列
- QPRRKLCILH RNPGRCYDKI PAFYYNQKKK QCERFDWSGC GGNSNRFKTI EECRRTCIG-OH
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特异性
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Toxin target: KV1.1, KV1.2, KV1.6, ASIC channels,
Disulfide bonds between: Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53 Gln1 - Pyrrolidone carboxylic acid -
产品特性
- A Blocker of KV1.1, KV1.2, KV1.6 and ASIC Channels
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应用备注
- Antigen Preadsorption Control: 10 - 500 nM
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说明
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Electrophysiology
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
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缓冲液
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
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储存条件
- 4 °C,-20 °C
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储存方法
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- alpha-Dendrotoxin
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背景
- Venom basic protease inhibitor 1 homolog, Toxin C13S2C3, α-DTX,α-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom by modification of the procedures of Harvey1 and Benishin2 and purified to homogeneity. α-Dendrotoxin blocks KV1.1 and KV1.2 channels (IC50= 0.4 to 4 and 1.1 to 12 nM in oocytes respectively, with higher values for mammalian cells).4 In addition, the toxin was shown to block KV1.6 (IC50= 9-25 nM).4α-Dendrotoxin was recently found to block ASIC currents in rat dorsal root ganglia with IC50 in the nM range5.
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分子量
- 7047 Da
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UniProt
- P00980
抗原
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