VSTM5 Protein (AA 28-146) (Fc Tag)
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- 抗原 See all VSTM5 products
- VSTM5 (V-Set and Transmembrane Domain Containing 5 (VSTM5))
- 蛋白类型
- Recombinant
- 产品特性
- AA 28-146
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宿主
- 小鼠
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资源
- CHO Cells
- 标记
- This VSTM5 protein is labelled with Fc Tag.
- 原理
- VSTM5 (mouse):Fc (mouse) (rec.) (non-lytic)
- 交叉反应
- 小鼠
- 产品特性
- The extracellular domain of mouse VSTM5 (aa 28-146) is fused to the N-terminus of the mouse Fc IgG2a (non-lytic mutant).
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test).
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V-Set and Transmembrane Domain Containing 5 (VSTM5) (AA 28-146) protein (Fc Tag)
VSTM5 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set and Transmembrane Domain Containing 5 (VSTM5) (AA 29-147) protein (Fc Tag)VSTM5 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 1 mg/mL after reconstitution.
- 浓度
- 1 mg/mL
- 缓冲液
- Contains PBS.
- 注意事项
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- VSTM5 (V-Set and Transmembrane Domain Containing 5 (VSTM5))
- 别名
- VSTM5 (VSTM5 产品)
- 背景
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V-set and Transmembrane Domain-containing Protein 5
The V-set and transmembrane domain-containing protein (VSTM) family is composed of 8 proteins: VSTM1v1, VSTM1v2, VSTM2a, VSTM2b, VSTM2L, VSTM3, VSTM4 and VSTM 5. Members of the VSTM family are associated with the regulation of functions of immune cells, adipose cells and neuronal cells. The VSTM family is an immunoglobulin (Ig) superfamily that shares structural similarities with the B7-like transmembrane proteins involved in immune regulation. VSTM1 and VSTM4 play positive and negative roles in macrophage activation, respectively. VSTM3 (TIGIT) acts as a co-inhibitory receptor that suppresses the cytokine production of T cells and NK cells. V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein highly expressed in the CNS, facilitates the formation of neuronal dendrites and protrusions such as dendritic filopodia. Regulatory roles of VSTM5 for in vitro and in vivo immune responses have been reported. VSTM5 functions as a novel immune checkpoint by regulating T cell proliferation and cytokine production, Treg generation by maintenance of T cell energy and possibly induction of T cell apoptosis.
- 分子量
- ~60kDa (SDS-PAGE)
- UniProt
- Q9D806
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