Diazepam Binding Inhibitor Protein (DBI) (AA 2-87) (His tag)
Quick Overview for Diazepam Binding Inhibitor Protein (DBI) (AA 2-87) (His tag) (ABIN7566020)
抗原
See all Diazepam Binding Inhibitor (DBI) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 2-87
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标记
- This Diazepam Binding Inhibitor protein is labelled with His tag.
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原理
- Acyl-CoA-binding Protein (human) (rec.) (His)
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交叉反应
- 人
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产品特性
- Human acyl-CoA-binding protein (aa 2-87) is fused at the C-terminus to a His-tag.
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内毒素水平
- <0.01EU/μg purified protein (LAL test).
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Diazepam Binding Inhibitor (DBI) (AA 1-87) protein (His tag)
DBI 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Diazepam Binding Inhibitor (DBI) (AA 1-87) protein (His-IF2DI Tag)DBI 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Diazepam Binding Inhibitor (DBI) (AA 1-104) protein (GST tag)DBI 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Diazepam Binding Inhibitor (DBI) (AA 1-87) protein (His tag)DBI 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Diazepam Binding Inhibitor (DBI) (AA 1-87) protein (His tag)DBI 宿主: E. coli 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 1 mg/mL after reconstitution
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浓度
- 1 mg/mL
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缓冲液
- Contains PBS.
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注意事项
- After reconstitution, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1 % BSA should be used for further dilutions.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
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- Diazepam Binding Inhibitor (DBI)
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别名
- Acyl-CoA-binding Protein
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背景
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ACBP, Diazepam-binding Inhibitor, DBI, Endozepine, EP
Acyl-coenzyme A (CoA)-binding protein (ACBP) is an ubiquitously expressed 86 aa polypeptide that binds medium- and long-chain acyl-CoA esters with very high affinity. It plays a role as an intracellular carrier of acyl-CoA esters and regulates lipid metabolism in the cytoplasm of most cell types. In addition to its function within the cells as acyl-coenzyme A (CoA)-binding protein, ACBP also functions as secreted protein called Diazepam-Binding Inhibitor (DBI) that can interact with the benzodiazepine-binding site of the gamma-aminobutyric acid (GABA) type A receptor, GABAAR, and modulate its activity. ACBP is secreted upon induction of autophagy (energy deficiency) in different organisms including mouse and human. ACBP levels correlate with human body mass index (BMI). Increasing ACBP levels in mice triggers lipogenesis, food intake and weight gain and neutralization of ACBP increases lipolysis, reduces food intake post-starvation and causes weight loss in mice. Obese patients exhibit elevated plasma levels of ACBP, while a reduction in the ACBP mRNA and ACBP plasma protein levels is observed in these patients after an important weight loss. ACBP might be useful for the prevention or treatment of obesity and metabolic syndrome diseases.
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分子量
- 12kDa (SDS-PAGE), 12kDa (Monomer by SEC)
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UniProt
- P07108
抗原
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